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  • Title: Inhibitory effect of IL-6-induced neuroendocrine cells on prostate cancer cell proliferation.
    Author: Wang Q, Horiatis D, Pinski J.
    Journal: Prostate; 2004 Nov 01; 61(3):253-9. PubMed ID: 15368468.
    Abstract:
    BACKGROUND: The role of increased neuroendocrine (NE) differentiation in prostate cancer (PCA) is not well understood. Long-term exposure of the prostate cancer cell line LNCaP to high concentrations of the cytokine interleukin-6 (IL-6) results in permanent transdifferentiation of these cells into a NE phenotype. In this study, we evaluated the effect of IL-6-induced NE cells on the growth of the PCA cell lines LNCaP, PC-3, and DU-145 in vitro. RESULTS: Co-culture of NE cells with PCA cells significantly inhibited DNA synthesis in all three PCA cell lines by 30-90% compared to controls. NE cell co-culture resulted in an increased percentage of PCA cells arrested in the S-phase of cell cycle and PCA cell apoptosis. CONCLUSIONS: Our results imply that NE cells suppress the proliferation of surrounding PCA cells by release of inhibitory factors.
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