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  • Title: Lack of reproductive photoresponsiveness and correlative failure to respond to melatonin in a tropical rodent, the cane mouse.
    Author: Bronson FH, Heideman PD.
    Journal: Biol Reprod; 1992 Feb; 46(2):246-50. PubMed ID: 1536900.
    Abstract:
    Cane mice (Zygodontomys brevicauda) are year-round breeders in Venezuela. As shown previously, these animals are not reproductively responsive to variation in photoperiod. In the present experiments, male cane mice were maintained on long or short day lengths (16L:8D or 8L:16D, respectively) and challenged with each of three experimental treatments known to "unmask" reproductive photoresponsiveness in laboratory rats: olfactory bulbectomy, prolonged food restriction, and exposure as neonates to a single injection of testosterone. Variation in photoperiod had no inhibitory effect on the responses of cane mice to any of these three treatments, as assessed by the weight of their testes and seminal vesicles. A fourth experiment demonstrated that cane mice are insensitive to 10 wk of continuous exposure to pharmacological levels of melatonin, again as assessed by reproductive organ weight. Likewise, a fifth experiment documented a lack of response to 10 wk of late-afternoon injections of massive amounts of melatonin. The cane mouse apparently is unique among the animals challenged so far in these ways in that it seems to have no vestige of reproductive photoresponsiveness.
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