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  • Title: Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.
    Author: Miller ML, Roller EE, Zhao RY, Leece BA, Ab O, Baloglu E, Goldmacher VS, Chari RV.
    Journal: J Med Chem; 2004 Sep 23; 47(20):4802-5. PubMed ID: 15369381.
    Abstract:
    To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or C-7 position and were found to be very cytotoxic against both normal and multi-drug-resistant (MDR) cells, as well as up to 30 times more soluble than paclitaxel in various buffer systems.
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