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  • Title: Experiences in providing a screening service for colorectal cancer from a pathology laboratory.
    Author: Edwards JE, Williams JA, Thomas DW.
    Journal: Pathology; 2004 Aug; 36(4):330-4. PubMed ID: 15370132.
    Abstract:
    AIM: To provide a colorectal cancer screening service for the general public, based on the detection of blood in faeces, that was effective, affordable and convenient. METHODS: Kits for collecting faecal specimens were sold directly to the public and, after collecting three specimens, kits were transported to the laboratory for testing by an immunochemical procedure involving a positive cut-off value. Reports were sent to participants and their nominated doctors who were requested to provide information on participants testing positive. RESULTS: Over a 10-year period, 35 139 kits were analysed and 5.63% were positive. After follow-up, 7.4% of positive testing participants were found to have colorectal cancer, 23.4% adenomas, 34.6% miscellaneous non-neoplastic pathology and in 25.0% no abnormality was found. Sixty-six per cent of cancers were early stage, Dukes stages A and B. There were 35 139 kits processed on 16 240 individuals, indicating that a number were repeat testing. CONCLUSIONS: The screening service was able to detect a high yield of colorectal pathology, especially early stage neoplasia which is curable, and encouraged repeat testing. Education of doctors about how to investigate a positive test, and of participants about symptoms, have been important lessons arising from this screening service.
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