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  • Title: Clinical associations and mechanisms of action of antisperm antibodies.
    Author: Chiu WW, Chamley LW.
    Journal: Fertil Steril; 2004 Sep; 82(3):529-35. PubMed ID: 15374685.
    Abstract:
    OBJECTIVE: To review and critique the current English literature describing the effects of antisperm antibodies (ASA) on mammalian fertility. DESIGN: A comprehensive English language literature was searched using Medline and by hand-searching. Emphasis was placed on clinically relevant articles. RESULT(S): Results from the studies were extrapolated and the effects of ASA on fertility described. CONCLUSION(S): Antisperm antibodies may interfere with fertility. Not all ASA cause infertility. Current tests cannot differentiate the infertility-related ASA from those that do not interfere with infertility, because the antigenic specificities of these ASA are not known. The antigens which the infertility-related ASA must be characterized to allow an accurate detection and proper treatment for couples with ASA.
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