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Title: [Experimental study of Ginkgo biloba exocarp polysaccharides on HL-60 cells in vitro]. Author: Xu A, Chen H, Sun B. Journal: Zhong Yao Cai; 2004 May; 27(5):361-3. PubMed ID: 15376393. Abstract: OBJECTIVE: To study the effect of Ginkgo biloba exocarp polysaccharides (GBEP) on HL-60 cells in vitro. METHOD: Cell culture, MTT, flow cytometry were performed to observe proliferation, apoptosis and changes of relevant gene expression of HL-60 cells. RESULT: GBEP (40-160 mg/L, 48 h) could inhibit HL-60 cells proliferation and the expression of proliferation-promotion gene c-myc, induce HL-60 cells apoptosis and down-regulate the expression of apoptosis-inhibitory gene bcl-2. CONCLUSION: Influence of GBEP on HL-60 cells proliferation and apoptosis may relate to its effects on the expression of proliferation-promotion gene c-myc and apoptosis-inhibitory gene bcl-2.[Abstract] [Full Text] [Related] [New Search]