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  • Title: Lymphocytic hypophysitis with a long latent period before development of a pituitary mass.
    Author: Wong RW, Ooi TC, Benoit B, Zackon D, Jansen G, Telner A.
    Journal: Can J Neurol Sci; 2004 Aug; 31(3):406-8. PubMed ID: 15376489.
    Abstract:
    BACKGROUND: Lymphocytic hypophysitis is an autoimmune condition that commonly presents in women of childbearing age as hypopituitarism and a sellar mass. CASE REPORT: A 66-year-old woman presented with anterior pituitary dysfunction. Computed tomography imaging revealed a small hypodensity that was not felt to be the cause of the pituitary dysfunction. Eight years later, her vision rapidly deteriorated and MRI showed a pituitary mass lesion causing optic chiasm compression. Histological examination of the partially resected gland revealed evidence of lymphocytic hypophysitis. CONCLUSION: Our patient is an example of the variable presentation and course of lymphocytic hypophysitis. Such a long latent period between the initial presentation of adenohypophysial hypofunction and optic chiasm compression due to an enlarging pituitary mass has not been reported.
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