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  • Title: Fragmentation of Golgi membranes by norrisolide and designed analogues.
    Author: Brady TP, Wallace EK, Kim SH, Guizzunti G, Malhotra V, Theodorakis EA.
    Journal: Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5035-9. PubMed ID: 15380194.
    Abstract:
    The effect of norrisolide (4) and designed analogues on the Golgi membranes is presented. We found that 4 is the first compound known to induce an irreversible vesiculation of these membranes. To investigate the chemical origins of this new effect we synthesized and evaluated a series of norrisolide analogues in which the chemical functionalities present in the parent structure were altered. Such structure/function studies suggest that the perhydroindane core of 4 is critical for binding to the target protein, while the C21 acetate unit is essential for the irreversible vesiculation of the Golgi membranes.
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