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  • Title: Does glutamine-enriched parenteral nutrition really affect intestinal morphology and gut permeability?
    Author: Hulsewé KW, van Acker BA, Hameeteman W, van der Hulst RR, Vainas T, Arends JW, van Kreel BK, von Meyenfeldt MF, Soeters PB.
    Journal: Clin Nutr; 2004 Oct; 23(5):1217-25. PubMed ID: 15380916.
    Abstract:
    BACKGROUND: Nutritional depletion has been related to low glutamine levels in plasma and gut mucosa. This study was set up to investigate the effects of glutamine-enriched total parenteral nutrition on intestinal morphology and permeability. METHODS: Twenty-three depleted patients were randomized and after stabilization baseline measurements were performed. Plasma glutamine concentrations, gut morphology (including proliferation and lymphocyte markers) and intestinal permeability were measured. After administration during 8-10 days of a glutamine enriched total parenteral nutrition or an isonitrogenous control solution the measurements were repeated. RESULTS: No significant changes in glutamine concentrations, intestinal permeability, mucosal morphology or gut mucosal inflammation were observed between groups. CONCLUSIONS: Glutamine enriched total parenteral nutrition in a depleted patient population does not result in improvements in gut morphology and gut barrier function.
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