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  • Title: Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2.
    Author: Ostareck-Lederer A, Ostareck DH.
    Journal: Biol Cell; 2004 Aug; 96(6):407-11. PubMed ID: 15384226.
    Abstract:
    Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.
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