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  • Title: [An efficiency study of transplantation of allogenic fibroblasts cultivated in collagen gel for the treatment of corneal burn defects in experiment].
    Author: Makarov PV, Gundarova RA, Terskikh VV, Vasil'ev AV, Khodzhabekian GV, Ivanov AA, Maksimov IB, Fedorov DN, Lapina LA, Shinin VV.
    Journal: Vestn Oftalmol; 2004; 120(4):27-9. PubMed ID: 15384844.
    Abstract:
    The paper contains the results of using a mew method applicable to regulation of corneal regeneration, i.e. transplantation of allogenic fibroblasts cultivated in collagen gel within an experimental model of acute alkali corneal burns in rabbits. Two experimental stages, involving 120 animals, were undertaken. The above method was used, at stage 1, on day 2 after trauma and, at stage 2, it was applied in two weeks after ocular burns with profound corneal defects were inflicted. The clinical, morphological and immune-histochemical examinations were used to show a high efficiency of the method in healing the corneal burn wounds; the mechanism of the therapeutic action of the transplant components exerted on regeneration of the affected cornea was investigated; finally, good outlooks for using the discussed method in clinical practice were proven.
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