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  • Title: Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral pi-allyl Pd-catalyst.
    Author: Kitagawa O, Yotsumoto K, Kohriyama M, Dobashi Y, Taguchi T.
    Journal: Org Lett; 2004 Sep 30; 6(20):3605-7. PubMed ID: 15387559.
    Abstract:
    [reaction: see text] N-monoallylation of meso-vicinal diamine bistrisylamides using a chiral pi-allyl-Pd catalyst proceeded in an enantioselective manner (up to 90% ee) to give desymmetrization products in good yields. The product was converted to the known sigma-receptor agonist in short steps. In addition, the present catalytic asymmetric N-allylation was applied to kinetic resolution of racemic-diamide.
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