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  • Title: Alterations of penicillin-binding proteins 1A, 2X, and 2B in Streptococcus pneumoniae isolates for which amoxicillin MICs are higher than penicillin MICs.
    Author: Kosowska K, Jacobs MR, Bajaksouzian S, Koeth L, Appelbaum PC.
    Journal: Antimicrob Agents Chemother; 2004 Oct; 48(10):4020-2. PubMed ID: 15388470.
    Abstract:
    Penicillin-binding proteins (PBPs) of 15 selected penicillin- and amoxicillin-resistant Streptococcus pneumoniae isolates (MICs of 2 to 8 and 8 to 16 microg/ml, respectively) were studied. In addition to typical changes in PBPs 1A and 2X, these strains had 10 unique changes in PBP 2B, including a (618)A-G substitution, which may be the key alteration associated with amoxicillin resistance.
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