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  • Title: Chronic inflammatory demyelinating polyradiculoneuropathy with autonomic involvement.
    Author: Yamamoto K, Watarai M, Hashimoto T, Ikeda S.
    Journal: Muscle Nerve; 2005 Jan; 31(1):108-12. PubMed ID: 15389651.
    Abstract:
    We report a case of chronic acquired neuropathy predominantly affecting sensory and autonomic nerves. Investigations showed a demyelinating polyradiculoneuropathy with axonal degeneration and depletion of postganglionic noradrenergic fibers in the rectal mucosa. Intravenous immunoglobulin and corticosteroid administration were effective in alleviating symptoms and improving electrophysiological abnormalities. This neuropathy may be a novel variant of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), in which autoimmunoreactivity is directed not only against myelin but also against axon- or ganglion-composing protein. Autonomic nerve involvement does not exclude a diagnosis of CIDP.
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