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  • Title: Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations.
    Author: Furukawa Y, Filiano JJ, Kish SJ.
    Journal: Mov Disord; 2004 Oct; 19(10):1256-8. PubMed ID: 15389992.
    Abstract:
    Amantadine suppressed severe levodopa-induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase I deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine-deficient metabolic disorders.
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