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Pubmed for Handhelds

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  • Title: Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's disease.
    Author: Fernandez HH, Trieschmann ME, Okun MS.
    Journal: Mov Disord; 2005 Jan; 20(1):104-5. PubMed ID: 15390047.
    Abstract:
    To determine whether psychiatrically stable patients with a history of drug-induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD) patients on quetiapine or clozapine, who were free of any on-going psychosis, to be slowly weaned off their antipsychotic drug. Before the study was aborted 6 PD patients (mean age, 78 years) with an average antipsychotic exposure of 20 months (5 on quetiapine, 1 on clozapine) were enrolled. After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses.
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