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  • Title: Effects of rivastigmine on motor and cognitive impairment in Huntington's disease.
    Author: de Tommaso M, Specchio N, Sciruicchio V, Difruscolo O, Specchio LM.
    Journal: Mov Disord; 2004 Dec; 19(12):1516-8. PubMed ID: 15390067.
    Abstract:
    To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration.
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