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  • Title: Glucose regulates the expression of Gi-proteins in cultured BC3H-1 myocytes.
    Author: Moises RS, Heidenreich KA.
    Journal: Biochem Biophys Res Commun; 1992 Feb 14; 182(3):1193-200. PubMed ID: 1540164.
    Abstract:
    To examine whether glucose has regulatory effects on the expression of Gi-proteins, BC3H-1 myocytes were incubated for 24 hr in the presence of various concentrations of glucose (0-25 mM) and the amount of Gi-proteins was detected by pertussis toxin ADP-ribosylation and immunoblot analysis. Both detection methods showed a progressive decrease in the amount of Gi proteins in cells treated with increasing concentrations of glucose. A maximal reduction of 40% was observed after a 24 hr exposure to 25 mM glucose. The reduction in Gi-proteins correlated with a decrease in insulin-stimulated glucose transport.
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