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  • Title: Differentiation of neuroblastoma cells correlates with an altered splicing pattern of tau RNA.
    Author: Montejo de Garcini E, Corrochano L, Wischik CM, Diaz Nido J, Correas I, Avila J.
    Journal: FEBS Lett; 1992 Mar 24; 299(1):10-4. PubMed ID: 1544466.
    Abstract:
    Morphological differentiation of N2A neuroblastoma cells is associated with an altered splicing of the gene of the microtubule-associated protein, tau. Two populations of RNA (coding for tau proteins containing three or four tubulin-binding motifs) are present in a similar proportion in undifferentiated neuroblastoma cells while in differentiated cells the proportion is changed in favour of that population coding for tau protein containing four tubulin-binding motifs. An increase in a high molecular weight tau isoforms correlates with the increase in the RNA population coding for four tubulin-binding motifs. A possible consequence of expressing a higher proportion of the tau protein containing four tubulin-binding motifs could be an increase in microtubule stability of differentiated neuroblastoma cells.
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