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  • Title: [Hominis placenta promotes melanocyte proliferation melanin synthesis and tyrosinase activity in vitro].
    Author: Yang L, Deng Y.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 Sep; 24(9):1040-1, 1044. PubMed ID: 15447857.
    Abstract:
    OBJECTIVE: To investigate the effects of Hominis placenta on melanocytes and tyrosinase activity in vitro. METHODS: MTT assay was used to assess the proliferation of melanocytes treated with Hominis placenta. Hunt method was employed to determine melanin synthesis and the oxidation rate of DL-dopa to evaluate the tyrosinase activity. RESULTS: Hominis placenta promoted melanocyte proliferation (P<0.01) and significantly increased the cell number (P<0.01), melanin synthesis (P<0.01), with the optimal concentration of 0.1g/L (P<0.01), and also enhanced tyrosinase activity (P<0.01) at the optimal concentration of 1 g/L (P<0.01). CONCLUSION: Hominis placenta promotes proliferation, melanin synthesis and tyrosinase activity of the melanocytes.
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