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  • Title: Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
    Author: Adams GE, Stratford IJ, Edwards HS, Bremner JC, Cole S.
    Journal: Int J Radiat Oncol Biol Phys; 1992; 22(4):717-20. PubMed ID: 1544844.
    Abstract:
    Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.
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