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  • Title: [The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate].
    Author: Zhang WG, Luo SJ, Tang SM, Liang J.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2004 May; 20(3):190-3. PubMed ID: 15449618.
    Abstract:
    OBJECTIVE: To study the association of TGF-alpha gene Taq I polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Chinese. METHODS: 107 patients with NSCL/P and 136 healthy controls were examined for TGF-alpha/Taq I genotypes. TGF-alpha/Taq I typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific Taq I restriction enzyme (PCR-RELP). RESULTS: The C2 allele frequency of TGF-alpha/Taq I in patients with NSCL/P (16%) was significantly higher than that in healthy controls (8%). The C2 genotype frequency of TGF-alpha/Taq I in NSCL/P patients with positive family history (12.5%) was significantly higher than that in healthy controls. CONCLUSION: These findings demonstrate the role of TGF-alpha as a gene of major effects in the development of nonsyndromic cleft lip with or without cleft palate clefts in human. These findings suggest that a family history of clefting may correlate with the TGF-alpha Taq I rare variation.
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