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  • Title: [Endocrine cells of rectal epithelium in health, in nonspecific ulcerative colitis and irritable colon syndrome in the treatment with prednisolone and salofalk and in the absence of treatment].
    Author: Kostiukovich SV, Anichkov NM, Ivanov VF, Oreshko L, Kudriashova GP, Medvedeva OI, Smirnova OA.
    Journal: Arkh Patol; 2004; 66(4):23-7. PubMed ID: 15449684.
    Abstract:
    The arrangement and ultrastructure of rectal intraepithelial endocrine cells in health, in nonspecific ulcerative colitis (NSUC) and in irritable colon syndrome (ICS) were studied with light and electron microscopy. An increase of the amount of these cells was registered at the initial stages of inflammation, whereas chronic and destructive states were accompanied by the cells decrease. A decrease of endocrine cells number in (NSUC) was pronounced more than in ICS. Compared to prednisolone, the treatment with salofalk produced a more positive effect on endocrine cells reproduction within the rectal lining. The endocrine cells ultrastructural changes found by the authors in ulcerative colitis and irritable colon showed similarity to those in other colon diseases.
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