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  • Title: Acute leukemia with a very high leukocyte count: confronting a medical emergency.
    Author: Majhail NS, Lichtin AE.
    Journal: Cleve Clin J Med; 2004 Aug; 71(8):633-7. PubMed ID: 15449758.
    Abstract:
    From 5% to 30% of adult patients with acute leukemias present with hyperleukocytosis--very high white blood cell counts (> 100,000 cells/mm3)--and symptoms of leukostasis. These conditions are a medical emergency that needs prompt recognition and initiation of therapy to prevent respiratory failure or intracranial hemorrhage. Patients should be referred as soon as possible for induction chemotherapy and leukapheresis.
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