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  • Title: Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.
    Author: Tan NC, Heron SE, Scheffer IE, Pelekanos JT, McMahon JM, Vears DF, Mulley JC, Berkovic SF.
    Journal: Neurology; 2004 Sep 28; 63(6):1090-2. PubMed ID: 15452306.
    Abstract:
    Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.
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