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  • Title: Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes.
    Author: Gasparac R, Taft BJ, Lapierre-Devlin MA, Lazareck AD, Xu JM, Kelley SO.
    Journal: J Am Chem Soc; 2004 Oct 06; 126(39):12270-1. PubMed ID: 15453752.
    Abstract:
    Electrochemical DNA detection systems are an attractive approach to the development of multiplexed, high-throughput DNA analysis systems for clinical and research applications. We have engineered a new class of nanoelectrode ensembles (NEEs) that constitute a useful platform for biomolecular electrochemical sensing. High-sensitivity DNA detection was achieved at oligonucleotide-functionalized NEEs using a label-free electrocatalytic assay. Attomole levels of DNA were detected using the NEEs, validating the promise of nanoarchitectures for ultrasensitive biosensing.
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