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  • Title: Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents.
    Author: Khanum SA, D VT, Shashikanth S, Firdouse A.
    Journal: Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5351-5. PubMed ID: 15454226.
    Abstract:
    Benzoylation of hydroxybenzophenones 1a-f affords substituted benzoyl phenyl benzoates 3a-f, which on Fries rearrangement using microwave irradiation led to a facile synthesis of solely dibenzoyl phenols 4a-f in excellent yield. The newly synthesized compounds were screened for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compound 4e showed more potent activity than the standard drugs at all doses tested.
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