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  • Title: Effect of M2 muscarinic receptor blockade in rats with haloperidol-produced catatonic syndrome.
    Author: Dagaev SG, Fil'ko OA, Kubarskaya LG, Khrabrova AV, Mukovskii LA, Glukhova RI, Sanotskii VI, Dolgo-Saburov VB.
    Journal: Bull Exp Biol Med; 2004 May; 137(5):468-70. PubMed ID: 15455120.
    Abstract:
    We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved in the regulation of dopamine concentration.
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