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  • Title: Synthesis and binding properties of calix[4]arenes with [2 + 2'] mixed ligating functional groups.
    Author: Baklouti L, Cherif J, Abidi R, Arnaud-Neu F, Harrowfield J, Vicens J.
    Journal: Org Biomol Chem; 2004 Oct 07; 2(19):2786-92. PubMed ID: 15455150.
    Abstract:
    A series of mixed [2 + 2'] p-tert-butylcalix[4]arene have been synthesised by selective 1,3-dialkylation of phenolic groups using various alkylating agents such as benzyl bromide, methyl iodide, ethyl bromoacetate, and 2-methoxyethyl tosylate. The extraction and complexation properties of the synthesized calixarenes towards alkali and alkaline earth metal cations have been investigated in acetonitrile by means of UV spectrophotometry and 1H NMR spectroscopy. The results show the formation of ML and/or ML2 species depending on the ligand and the cation. The enthalpies and entropies of complexation of alkali metal cations by a tetraglycol, diglycol-dibenzyl and diglycol-diester derivatives have been obtained from calorimetric measurements. The results revealed that the formation of ML species is controlled by enthalpy while the formation of ML2 from ML is entropy driven.
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