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  • Title: Asparaginase inhibition of adhesion of type 1-fimbriated and P-fimbriated Escherichia coli to epithelial cell receptors.
    Author: Wehner MR, Koch SR, Kindinger L, Nelson N, Cowan MM.
    Journal: Appl Microbiol Biotechnol; 2004 Nov; 66(1):71-3. PubMed ID: 15455180.
    Abstract:
    The 3D structures of Fim H and PapG proteins complexed with the host carbohydrate receptor demonstrate that both utilize binding-pocket asparagines for contact or stabilization with the carbohydrate. Pretreatment of whole bacteria with asparaginase resulted in decreased fimbriae-mediated attachment to urinary epithelial cells. Enzyme treatment of bacteria pre-adhered to epithelial cells removed more uropathogenic E. coli than the indigenous flora attached to them.
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