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  • Title: [Single nonselective cation channels activated by muscarinic agonists in smooth muscle cells of the guinea-pig small intestine].
    Author: Dresviannikov AV, Zholos AV, Shuba MF.
    Journal: Fiziol Zh (1994); 2004; 50(4):85-91. PubMed ID: 15460032.
    Abstract:
    The carbachol-evoked inward cationic current in guinea-pig ileum smooth muscle cells is comprised of three types nonselective cationic channels (NSCC) with small (10 +/- 2 pS), medium (56 +/- 8pS) and large (135 +/- 14 pS) unitary conductance. All three types of NSCC could be activated by external application of carbachol as well as by internal application of GTPgS. It was found that behavior of carbachol- and GTPgammaS-evoked whole-cell current is mainly determined by the properties of medium conductance channels. The U-shaped I-V relationship of the whole-cell cationic current at negative potentials range arrives from voltage-dependence of its Po of this channel.
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