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  • Title: Ondansetron amelioration of scopolamine induced cognitive deficits in three-panel runway apparatus in rats.
    Author: Kumar N, Kela AK.
    Journal: Indian J Exp Biol; 2004 Sep; 42(9):919-21. PubMed ID: 15462187.
    Abstract:
    Effect of ondansetron (5-HT3-receptor antagonist) was studied on the working memory deficits induced by scopolamine, a muscarinic receptor antagonist in rats using a three-panel runway apparatus. Varying doses of scopolamine (0.1-0.56mg/kg, ip) were administered alone or in combination with ondansetron (0.01-1.0 mg/kg, ip) and memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with ondansetron (1.0 mg/kg) significantly reduced the scopolamine-induced working memory deficits.
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