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Title: Novel spironolactone-analogs as impurities in spironolactone. Author: Chen H, Wang XY, Yang ZD, Li YC. Journal: Steroids; 2004 Sep; 69(10):647-52. PubMed ID: 15465109. Abstract: Six novel spironolactone-analogs steroids (3-8) were isolated from spironolactone by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. Two of the analogs (3 and 7) were confirmed by X-ray crystallography. The A-ring of compounds 3-7 is opened at C-2C-3 bond, and compound 7 is an organic polysulfide, which has a rare, nine-membered ring with a five sulfur atom bridge.[Abstract] [Full Text] [Related] [New Search]