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  • Title: Antioxidant properties of 3-hydroxycoumarin derivatives.
    Author: Bailly F, Maurin C, Teissier E, Vezin H, Cotelle P.
    Journal: Bioorg Med Chem; 2004 Nov 01; 12(21):5611-8. PubMed ID: 15465339.
    Abstract:
    A series of hydroxylated 3-hydroxycoumarins was synthesised by the reaction of 3-aryl-2-hydroxypropenoic derivatives with boron tribromide. They were evaluated for their ability to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical, the superoxide anion radical, the hydroxyl radical and the peroxynitrite anion and to inhibit copper-induced human LDL peroxidation. The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C. These compounds form o- and p-quinonoid derivatives upon radical scavenging and may serve as new lead compounds for pharmacological investigations.
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