These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Volumetric neural correlates of antisaccade eye movements in first-episode psychosis.
    Author: Ettinger U, Kumari V, Chitnis XA, Corr PJ, Crawford TJ, Fannon DG, O'ceallaigh S, Sumich AL, Doku VC, Sharma T.
    Journal: Am J Psychiatry; 2004 Oct; 161(10):1918-21. PubMed ID: 15465994.
    Abstract:
    OBJECTIVE: The authors investigated the structural brain correlates of antisaccade performance. METHOD: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. RESULTS: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. CONCLUSIONS: These findings point to altered structure-function relationships in first-episode psychosis.
    [Abstract] [Full Text] [Related] [New Search]