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  • Title: A single amino acid substitution converts gamma-glutamyltranspeptidase to a class IV cephalosporin acylase (glutaryl-7-aminocephalosporanic acid acylase).
    Author: Suzuki H, Miwa C, Ishihara S, Kumagai H.
    Journal: Appl Environ Microbiol; 2004 Oct; 70(10):6324-8. PubMed ID: 15466585.
    Abstract:
    The aspartyl residue at position 433 of gamma-glutamyltranspeptidase of Escherichia coli K-12 was replaced by an asparaginyl residue. This substitution enabled gamma-glutamyltranspeptidase to deacylate glutaryl-7-aminocephalosporanic acid, producing 7-aminocephalosporanic acid, which is a starting material for the synthesis of semisynthetic cephalosporins.
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