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  • Title: Sinus histiocytosis with massive lymphadenopathy associated with malignant lymphoma.
    Author: Shoda H, Oka T, Inoue M, Kusaka S, Tsuneyoshi H, Miyazaki J, Sunaga S.
    Journal: Intern Med; 2004 Aug; 43(8):741-5. PubMed ID: 15468978.
    Abstract:
    Sinus histiocytosis with massive lymphadenopathy (SHML) is a distinct benign clinicopathological entity, characterized by painless enlargement of lymph nodes due to sinus histiocytosis. Here, we report a case of SHML with diffuse large B-cell lymphoma. A 64-year-old man was admitted to our hospital because of fever. He presented with enlargement of a small cervical lymph node and huge abdominal paraaortic lymphadenopathy. Cervical lymph node biopsy revealed SHML and bone marrow biopsy showed infiltration of large B-cell lymphoma. Several cases of SHML associated with lymphoma have been documented to date, but this type of simultaneous occurrence has not yet been reported.
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