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  • Title: [A new synthesis of alpha-methylspermidine].
    Author: Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Kritsyn AM, Khomutov AR.
    Journal: Bioorg Khim; 2004; 30(4):441-5. PubMed ID: 15469020.
    Abstract:
    A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N'-acetyltransferase, from ethyl 3-aminobutyrate was achieved in a high overall yield.
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