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  • Title: [Signal transduction pathways and transcription factors involved in luteinizing hormone beta subunit gene expression].
    Author: Li L, Wang GL.
    Journal: Sheng Li Ke Xue Jin Zhan; 2004 Jul; 35(3):215-8. PubMed ID: 15469090.
    Abstract:
    The pulsatile pattern of the hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in reproductive function by regulating the biosynthesis and secretion of the pituitary gonadotropins. Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) are heterodimeric glycoproteins composed of a common peptide, the glycoprotein hormone subuint alpha, and either a specific FSHbeta or LHbeta polypeptide. GnRH regulates LHbeta gene expression through GnRH receptor activation of the protein kinase C (PKC) and calcium signaling cascades. Recently, many transcription factors, such as early growth response-1 (Egr-1), steroidogenic factor-1 (SF-1), Ptx1 and Sp1, have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene.
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