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  • Title: The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.
    Author: Boxem M, Tsai CW, Zhang Y, Saito RM, Liu JO.
    Journal: FEBS Lett; 2004 Oct 08; 576(1-2):245-50. PubMed ID: 15474045.
    Abstract:
    We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner.
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