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  • Title: The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis.
    Author: Cao X, Yang D, Song M, Murphy A, Parthasarathy S.
    Journal: Fertil Steril; 2004 Oct; 82 Suppl 3():999-1007. PubMed ID: 15474064.
    Abstract:
    OBJECTIVE: To determine the inflammatory response in the peritoneal cavity by the presence of endometrial cells and the role of the mesothelium. DESIGN: In vivo study using mice. SETTING: University research laboratory. ANIMAL(S): Female Swiss Webster mice, 8 to 10 weeks old. INTERVENTION(S): Homogenous mouse endometrial epithelial and stromal cells were injected intraperitoneally. Peritoneal lavage and mesothelium were collected 4 to 72 hours after the administration. MAIN OUTCOME MEASURE(S): We determined the number of peritoneal macrophages, and the production and gene expression of monocyte chemotactic protein-1 (MCP-1/JE), interleukin 1alpha (IL-1alpha), and interleukin 6 (IL-6). RESULT(S): The intraperitoneal administration of endometrial cells increased the number of peritoneal macrophages, production of MCP-l, IL-1alpha, and IL-6, and expression of mesothelial MCP-1/JE, IL-1alpha, and IL-6 genes in recipient mice. CONCLUSION(S): These results suggest that retrograde menstruation could account for the increased presence of inflammatory mediators in the peritoneal cavity of women with endometriosis. The mesothelium could play an active role in endometriosis in addition to providing an attachment stratum for the endometrial cells.
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