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  • Title: Acute megakaryoblastic leukemia with t(17;22)(q21;q13) and liver dysfunction.
    Author: Chitlur MB, Bhambhani K, Mohamed AN, Ravindranath Y, Savaşan S.
    Journal: Cancer Genet Cytogenet; 2004 Oct 15; 154(2):167-8. PubMed ID: 15474155.
    Abstract:
    The t(1;22)(p13;q13) is associated with acute megakaryoblastic leukemia (AMKL) seen mostly in young infants and known to have a poor prognosis. A 5-year-old child had prolonged prothrombin and partial thromboplastin times, low albumin, and decreased vitamin K-dependent coagulation factors and factor V activities at the time of AMKL diagnosis. All of these factors normalized following chemotherapy when remission was achieved. Cytogenetic analysis revealed a female karyotype with a balanced t(17;22)(q21;q13). Here, we present an AMKL pediatric case with a novel translocation and significant hepatocellular dysfunction that resolved with chemotherapy. The t(17;22) (q21;q13) may represent a variant of t(1;22)(p13;q13).
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