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  • Title: Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum.
    Author: Cai XF, Lee IS, Dat NT, Shen G, Kim YH.
    Journal: Phytother Res; 2004 Aug; 18(8):677-80. PubMed ID: 15476312.
    Abstract:
    Six diterpenoids and two diterpene glycosides were isolated from the dichloromethane and the water fractions of Acanthopanax koreanum roots, respectively. Of these compounds, 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid containing an isovaleryloxy group at C-17 was found to exhibit the strongest inhibitory activity (IC(50), 6.7 microm) against NFAT transcription factor. However, sumogaside, 16alpha-hydroxy-ent-kauran-19-oic acid and paniculosides IV containing a hydroxy group at C-16 or a glycoside at C-4 carboxyl acid showed no activity.
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