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  • Title: Visually evoked blood flow responses and vasoneuronal coupling in partial epilepsy.
    Author: Panczel G, Pohlmann-Eden B.
    Journal: Acta Neurol Scand; 2004 Nov; 110(5):308-12. PubMed ID: 15476459.
    Abstract:
    OBJECTIVES: Increased metabolic demand is coupled with increased regional blood flow. The decreased vasoreactivity in epileptic patients however, prompts an impact of epileptic dysfunction on vasoneuronal coupling. MATERIAL AND METHODS: Blood flow velocities during visual stimulation were monitored by TCD in both posterior cerebral arteries in 20 epileptic patients and 20 control persons, response-amplitudes (RA) and pulsatility indices (PI) were analyzed. RESULTS: The RAs were significantly smaller in patients than in controls (28.4 +/- 5.7% vs 38.4 +/- 10.2%; P < 0.001). RAs were larger in the right side and these right-sided responses were significantly smaller in patients with right-sided vs left-sided epileptic foci (27.9 +/- 5.5% vs 36.1 +/- 4.5%; P < 0.005). The PI during stimulation was significantly larger in patients than in controls (0.92 +/- 0.11 vs 0.74 +/- 0.15; P < 0.001). CONCLUSION: Our data suggest an impaired vasoneuronal coupling in focal epilepsy, and support the view that the right hemisphere might be more important for color processing.
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