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  • Title: Detection of Helicobacter pylori in bile of cats.
    Author: Boomkens SY, Kusters JG, Hoffmann G, Pot RG, Spee B, Penning LC, Egberink HF, van den Ingh TS, Rothuizen J.
    Journal: FEMS Immunol Med Microbiol; 2004 Nov 01; 42(3):307-11. PubMed ID: 15477044.
    Abstract:
    Lymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive (p=0.44). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir.
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