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  • Title: Anti-cyclic citrullinated antibodies: complementary to IgM rheumatoid factor in the early diagnosis of rheumatoid arthritis.
    Author: Solanki K, Spellerberg M, Chapman P, Moller P, O'Donnell J.
    Journal: N Z Med J; 2004 Oct 08; 117(1203):U1097. PubMed ID: 15477921.
    Abstract:
    AIMS: To compare the diagnostic sensitivity of anti-cyclic citrullinated (CCP) antibodies and rheumatoid factor (RF) in rheumatoid arthritis (RA) within a general hospital setting. METHOD: Using the American College of Rheumatology (ACR) classification criteria as a gold standard, the frequency of RF and anti-CCP antibody positivity was compared between two groups of RA patients: those with disease duration less than 2 years (early RA, ERA) and those with disease duration more than 2 years (late RA, LRA). RESULTS: In ERA, the diagnostic sensitivity of RF and anti-CCP antibodies was 57% and 79% respectively. In LRA, it was 81% and 84% respectively. CONCLUSION: Anti-CCP antibodies are 20% more sensitivity than RF in the diagnosis of early RA.
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