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  • Title: Screening extracts of Madagascan plants in search of antiplasmodial compounds.
    Author: Rasoanaivo P, Ramanitrahasimbola D, Rafatro H, Rakotondramanana D, Robijaona B, Rakotozafy A, Ratsimamanga-Urverg S, Labaïed M, Grellier P, Allorge L, Mambu L, Frappier F.
    Journal: Phytother Res; 2004 Sep; 18(9):742-7. PubMed ID: 15478200.
    Abstract:
    One hundred and ninety plants, of which 51 are used to treat malaria in traditional medicine, were collected in five different ecosystems of Madagascar for a screening programme devoted to the search of naturally-occurring antimalarial compounds. Thirty-nine plants, of which 12 are used as herbal antimalarials, were found to display in vitro activity against Plasmodium falciparum with a median inhibitory concentration (IC50) lower than 5 microg/ml while 9 had an IC50 ranging from 5 to 7.5 microg/ml. Seventeen of them exhibited cytotoxic effects on murine P388 leukemia cells with an IC50 < 10 microg/ml. The biological activities were mostly located in the ethyl acetate fractions. Bioassay-directed fractionation is underway to isolate the active constituents.
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