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  • Title: [Effects of Alfatesine (ct 1341) on cerebral blood flow and metabolism in man. Global and regional changes].
    Author: Renou AM, Vernihiet J, Orgogozo JM, Caille JM.
    Journal: Ann Anesthesiol Fr; 1976; 17(11):1247-54. PubMed ID: 15480.
    Abstract:
    The effects of Alfatesine on local cerebral blood flow and on cerebral oxygen consumption were studied in 5 normal subjects and in 6 patients suffering from diffuse vascular repercussion of cerebral distress. There is a 75 p. 100 fall in cerebral blood flow in the gray substance and a parallel fall in oxygen consumption. At rest, the caracteristic anaesthetic action modifies the caracteristical distribution of blood flows in the cortex. A relative hyperemia appears in the area of the central sulcus. Those focal changes could not be found in the group of pathogical patients.
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