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  • Title: [Still no indications that the treatment of growth hormone deficient adults with growth hormones is unsafe].
    Author: Janssen JA, Visser WE, van der Lely AJ.
    Journal: Ned Tijdschr Geneeskd; 2004 Jul 24; 148(30):1486-9. PubMed ID: 15481571.
    Abstract:
    Although more than 100,000 patients worldwide are estimated to have received growth-hormone treatment, there are still widespread doubts about the safety aspects of growth-hormone treatment of adults with growth-hormone deficiency (GHD). The available data are scarce and the follow-up time is short. The data do not suggest that growth-hormone treatment increases the incidence or regrowth of pituitary adenomas in adults with GHD. Equally there are no data which suggest that growth-hormone treatment of adults with GHD increases the incidence of cancer, provided that concentrations of the insulin-like growth factor I (IGF-I) achieved in the blood remain within the normal range for the age of that patient. No increase in diabetes mellitus has been reported following the introduction of growth-hormone treatment in adult GHD patients. Insulin sensitivity does not appear to change in GHD patients on growth-hormone treatment as long as relatively low physiological doses of growth hormone are used. Whether growth-hormone therapy in adult patients with GHD will prove safe in the long term remains to be established.
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