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  • Title: Neuroendocrine hypothesis of aging: the role of corticoadrenal steroids.
    Author: Valenti G.
    Journal: J Endocrinol Invest; 2004; 27(6 Suppl):62-3. PubMed ID: 15481804.
    Abstract:
    The age-related modifications of neuroendocrine secretions normally capable of integrative activity in the whole body might partly promote and amplify many aging phenomena. The quantitative and qualitative changes of hypothalamus-pituitary-adrenal axis are a significant example. The dampening of cortisol and dehydroepiandrosterone (DHEA) circadian fluctuation and the progressive decrease of DHEA/cortisol ratio are at the basis of multiple clinical implications: the shift from anabolic to catabolic status, the activation of atherosclerosis progression, the deterioration of immune competence, the impairment of cognitive and affective performances and the glico- and lipometabolic disorders. The hypothesis of a DHEA supplementation strategy comes out from these premises.
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